When it comes to coming off an anabolic steroid cycle, especially those involving harsh or aromatizable steroids, antiestrogens such as Arimidex could be helpful in more than just a way. The fact that Arimidex, also known as Anastrozole and Liquidex, enhances bioavailability of anabolic steroids used during a steroid cycle and restores the natural production of hormones, such as testosterone, means that sportsmen on steroids have enough reasons to admire it.
The antiestrogen is commonly used by budding as well as professional sportsmen using anabolic steroids and performance enhancing drugs to hit harder, jump higher, run faster, and look bigger. By reducing or eliminating the formation of excess estrogens, Arimidex helps steroid users stay away from estrogenic side effects such as gynecomastia, oily skin, water retention, and acne besides restoring the natural production of hormones, such as testosterone. It is also admired for its potential of reducing the blood estradiol concentrations besides minimizing the size and growth of cancerous tumors.
The aromatase inhibitor belongs to the category of 3rd generation selective oral aromatase inhibitors and is chemically described as 1,3-Benzenediacetonitrile, a, a, a’, a’-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl). Its molecular formula is C17H19N5 and the active ingredient in Arimidex tablets is 1 mg of anastrozole, a non-steroidal aromatase inhibitor and each tablet contains lactose, magnesium stearate, hydroxypropylmethylcellulose, polyethylene glycol, povidone, sodium starch glycolate, and titanium dioxide as the inactive ingredients.
Medically, Anastrozole or Arimidex is recommended for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer. It is worthwhile to note that patients with ER-negative disease and those who did not respond to previous tamoxifen therapy often don’t respond to this drug.
One of the biggest advantages of oral Arimidex is that it enters the liver where more than 90 percent of it gets broken down into inactive metabolites. Moreover, the antiestrogen does not get excreted in the urine that makes it safe and useful for people suffering with kidney impairment. Moreover, it is considered better by many sportsmen over Clomid and Nolvadex as Arimidex prevents the aromatase compound for limiting the estrogen production while Clomid and Nolvadex reduce estrogenic action in the body. In order to reap the maximum advantages of this antiestrogen, it is best used along with Propecia (Finasteride). While Arimidex inhibits estrogen production, Propecia limits the transformation of testosterone to dihydrotestosterone besides reducing incidents of hair loss.
Use of this antiestrogen is not recommended to premenopausal females and those having an existing allergy to the drug or any of its ingredients. People already making use of estrogen containing therapies should avoid using it as such use may reduce pharmacological action of presently-used drugs. The antiestrogen is also not recommended when users are already being administered with any prescription or nonprescription medicine, herbal preparation, or dietary supplements. Arimidex should not be taken with Tamoxifen and patients can expect an increased level of cholesterol while receiving Anastrozole. Use of this drug may cause fetal harm when administered to a pregnant woman.
Premenopausal women with breast cancer derive no benefit with use of this drug and women who are or may become pregnant should avoid using it. It is recommended to women who have finished menopause for treating early breast cancer, after surgery (with or without radiation) and provide dramatic relief to women whose breast cancer is hormone receptor-positive or for treating advanced breast cancer if the disease has spread or if the disease has spread after tamoxifen therapy.
The antiestrogen is also not recommended to those using hormone replacement therapy, estrogen creams, vaginal suppositories, vaginal rings, and birth control pills and the dosage should be in strict conformity with medical advice. No two doses of Anastrozole should be taken at the same time. In case a dose has been missed accidentally, the missed dose should be skipped and the next scheduled dose should be taken at the next dosage time. Pregnant women or those who may become pregnant should avoid handling or breaking Arimidex tablets as the drug can be absorbed through the skin.
Medical advice should be sought on an immediate basis if side effects such as swollen glands, bone fractures, swelling in hands or feet, sudden numbness or weakness, or sudden headache, confusion, problems with vision, speech, or balance are experienced after making use of Arimidex. Before seeking medical advice, potential users of Arimidex should disclose medical history, especially if suffering from health complications such as liver disease, high blood pressure, heart disease (such as ischemic heart disease, history of chest pain), brittle bone disease (osteoporosis), blood clots. Since use of Arimidex may lead to dizziness, it is best to avoid heavy machines, use alcoholic beverages, or perform any activity that requires alertness.
The recommended dose of this antiestrogen is one 1 mg tablet, once a day, with or without food. Abuse of Arimidex may lead to side effects, including hot flashes, asthenia, arthritis, pain, arthralgia, pharyngitis, hypertension, depression, nausea and vomiting, rashes, osteoporosis, fractures, back pain, insomnia, pain, headache, bone pain, peripheral edema, increased cough, dyspnea, and lymphedema. The list of side effects associated with the antiestrogen may even include constipation, diarrhea, nausea, vomiting, upset stomach, loss of appetite, body aches and pains, breast swelling/tenderness/pain, headache, dry mouth, scratchy throat, increased cough, dizziness, trouble sleeping, tiredness/weakness, flushing, sweating, vaginal bleeding, hair thinning, and weight change. Though very rare, Arimidex side effects may include chest pain, jaw/left arm pain, trouble breathing, confusion, fainting, slurred speech, and weakness on one side of the body. Users of the drug should indulge into eating well-balanced meals that contain adequate calcium and vitamin D, stop smoking, and limit alcohol.
Arimidex must be stored at a controlled room temperature of 20-25°C (68-77°F) with excursions permitted to 15° to 30°C (59° to 86°F) and in a cool place and guarded against direct light, heat, sources of ignition, unauthorized use, children, and pets. In case of expired tablets, the same should be discarded after having a word with a pharmacist or local waste disposal company on how to safely discard Arimidex.